The interaction between the immune and endocrine system in carp (WU) Application of coronaviruses in virotherapy (Univ. of Utrecht) Research on Kunjin virus (Univ. of Queensland, Australia)
Supervisors:
Prof. Huub Savelkoul Dr. Lidy van Kemenade (WU), Dr. Pierre Boudinot (INRA)
CoOperators:
Jean-Pierre Levraud (Institut Pasteur)
Financer:
INRA, WUR
Start date:
01 February 2007
End date:
01 February 2011
Introduction:
TRIM proteins constitute a large protein family in vertebrates that share a tripartite motif (TRIM) at the N-terminus: a ring finger, a B-Box domain and a coiled-coil (RBCC). TRIM proteins are intracellular proteins and are implicated in cell growth and differentiation. The last few years the roles of TRIM proteins during virus infection is becoming more evident. Previous work showed that TRIM gene expression is induced during virus infection in rainbow trout. The trout TRIM gene belongs to a large multigene TRIM family and is present in other teleost fish species. The aim of the project is to further describe and characterize this multigene TRIM family in teleost fish.
Results:
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Articles:
Antibody-mediated targeting of viral vectors to the Fc receptor expressed on acute myeloid leukemia cells. Leukemia. 2006 Dec;20(12):2182-4 Corticotropin-releasing factor (CRF) and CRF-binding protein expression in and release from the head kidney of common carp: evolutionary conservation of the adrenal CRF system. J Endocrinol. 2007 Jun;193(3):349-57.
